Changes of myocardial oxygen consumption, creatine kinase and electrocardiogram in patients with myocardial infarction treated with urokinase
DAN Li-jun
Abstract：Objective To observe the influences of urokinase on myocardial oxygen consumption, creatine kinase (CK) and electrocardiogram (ECG) in patients with acute myocardial infarction (AMI).Methods AMI patients (n=122) were chosen from Dec. 2012 to Dec. 2014, and divided into control group (n=53) and test group (n=69). The control group was given supportive therapy, intravenous injection of low molecular weight heparin (1.5 million U) and oral aspirin (300 g), and test group was given additionally urokinase. The changes of myocardial oxygen consumption, CK and ECG ST-segment change rate (ratio of ST-segment decrease after treatment to that before treatment) were observed continuously after treatment. Results After treatment, the difference in ST-segment change rate and revascularization rate was significant between 2 groups (P<0.01). The difference in blood pressure was not significant between 2 groups (P>0.01), and heart rate and myocardial oxygen consumption were significantly lower in test group than those in control group (P<0.05). The difference in CK was not significant at the first between 2 groups (P>0.05) after treatment, and after 16 h (23.32±7.73), 20 h (17.45±7.44) and 24 h (8.47 ±3.4) the difference was significant (P<0.05). After treatment, the difference in CK enzyme peak was significant between 2 groups (P<0.05) and forward lead of peak was less than 16 h in test group.Conclusion Urokinase combining aspirin has reliable curative effect on AMI in elderly patients.
Keywords：UrokinaseAspirinAcute myocardial infarction
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 100-102 )