Relationship between acute myocardial infarction and level of serum uric acid

ZHANG Qing-yun; ZHOU Yun-ling; LUO Jia; ZOU Lan; LUO Hui; XIAO Lian

doi:10.3969/j.issn.1674-4055.2016.01.27

Abstract：Objective To investigate the relationship between acute myocardial infarction (AMI) and level of serum uric acid (UA).Methods AMI patients (n=280, male 166, female 114, aged from 23 to 75 and average age=56.39±12.93) were chosen from Feb. 2009 to Dec. 2014 as AMI group, and non-AMI patients (n=100, male 59, female 41, aged from 26 to 69 and averaged age=55.10±14.41) were chosen as control group at the same time. All AMI patients were given coronary angiography (CAG) within 6 h for determining infarction vessels, and then divided into single-focus group (n=178) and multi-focus group (n=102) based on outcomes of electrocardiogram (ECG). The levels of serum UA, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) were detected, and meanwhile creatine kinase MB (CK-MB) was detected after chest pain attack for 12 h. The changes of left ventricular end-diastolic inner diameter (LVEDd) were detected, and left ventricular ejection fraction (LVEF) was detected by using Simpson's method.Results The level of serum UA was (352.18±65.20) mmol/L and (301.37±72.08) mmol/L in control group (P<0.01). The levels of serum UA [(322.17±69.40) mmol/Lvs. (374.38±54.39) mmol/L], CK-MB [(40.32±18.41) U/Lvs. (75.50 ±20.27) U/L], LVEDd [(47.53±6.39) mmvs. (54.30±5.13) mm] increased, and LVEF [(61.27±7.18)%vs. (41.94 ±8.54)%] decreased in multi-focus group compared with multi-focus group (all P<0.01). The difference in level of blood fat had no statistical significance (all P>0.05). The correlation analysis showed that serum UA was positively correlated to CK-MB (r=0.589,P<0.05), negatively correlated to LVEF (r=-0.605,P<0.05) and not correlated to LVEDd (P>0.05).Conclusion The level of serum UA increases in patient with AMI, and myocardial injury will be more serious as increase of serum UA level and decrease of heart function.