Relationship among ratio of urinary micro albuminuria to creatinine, ambulatory blood pressure level and blood pressure variability in hypertensive patients
CHEN Yun
ZHANG Yuan-yuan
LIU Hai-ting
LIU Xin-can
Abstract：Objective To investigate the relationship among ratio of urinary micro albuminuria (U-mAlb) to creatinine (Cr, UACR), ambulatory blood pressure (BP) level and blood pressure variability (BPV) in hypertensive patients.Methods The patients with primary hypertension (n=90, male 57, female 33 and average age=41.2±6.3) were chosen from Jun. 2014 to Jun. 2015, and then divided into control group (UACR<30 mg/g,n=52) and U-mAlb group (30 mg/g≤UACR<300 mg/g,n=38) according to detected UACR. The changes of 24-h mean systolic blood pressure (SBP) and standard deviation, 24-h mean diastolic blood pressure (DBP) and standard deviation, daytime mean SBP and standard deviation, daytime mean DBP and standard deviation, nighttime mean SBP and standard deviation and nighttime mean DBP and standard deviation were compared in 2 groups. The standard deviations of BP and variation coefficient were taken as indexes of BPV. The correlation between UACR and BPV was analyzed in hypertensive patients.Results The course of hypertension was longer in U-mAlb group than that in control group (P<0.05). Compared with control group, 24 h mean SBP and DBP, daytime mean SBP and DBP and nighttime mean DBP increased in U-mAlb group (all P<0.05). Compared with control group, 24 h SBP standard deviation and variation coefficient and daytime SBP standard deviation and variation coefficient increased in U-mAlb group (all P<0.05). The results showed that 24 h mean DBP (β=0.202,P=0.007) and 24 h SBP standard deviation (β=0.986, P=0.001) were positively correlated to UACR, and 24 h DBP standard deviation was not correlated to UACR. Conclusion The 24 h mean DBP and 24 h SBP standard deviation is significantly correlated to increase of UACR level in patients with primary hypertension.
Keywords：Primary hypertensionBlood pressure variabilityRatio of urinary micro albuminuria to creatinine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 75-77 )