Influence of low-dose aspirin combining atorvastatin on carotid atherosclerosis in elderly patients with coronary heart disease
ZHU Shi-guo
WANG Ming-song
Abstract：Objective To observe the curative effect of low-dose aspirin combining atorvastatin on carotid atherosclerosis in elderly patients with coronary heart disease (CHD).Methods The elderly patients with CHD (n=126, male 68, female 58, aged from 60 to 75 and average age =64±8.2) were chosen from Jan. 2008 to Dec. 2012, and they had carotid atherosclerotic plaques diagnosed by color Doppler ultrasonic examination. All patients were randomly divided into group A and group B (eachn=63). The difference in sex, age, disease type, Doppler outcome, blood fat, blood sugar and ECG results had no statistical significance between 2 groups (all P>0.05). Based on routine treatment, group A was orally given atorvastatin (20 mg/d) and aspirin (100 mg/d), and group B, only atorvastatin (20 mg/d) for 12 m. The levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) were detected before and 12 m after treatment. The quantity and types of atherosclerotic plaques were detected by using color Doppler ultrasonic diagnostic apparatus in bilateral common carotid artery (CCA), internal carotid artery (ICA) and external carotid artery (ECA). The changes of carotid artery intima-media thickness (CA-IMT) were detected before and 6 m and 12 m after treatment.Results The color Doppler ultrasonic examination showed that IMT and plaque quantity decreased significantly in 2 groups after treatment for 6 m and 12 m (all P<0.05). Compared with group B, plaque quantity decreased significantly in group A after treatment for 12 m [(30.3±0.06)vs. (26.4±0.07), all P<0.05]. The quantity of flat plaques [(5.04±1.25)vs. (4.03±1.20)] and hard plaques [(10.14±1.06)vs. (8.82 ±1.18)] decreased in group A compared with group B after treatment for 12 m (all P<0.05). The levels of blood fat and hs-CRP decreased in 2 groups after treatment for 12 m (all P<0.05). The level of hs-CRP decreased in group A compared with group B [(3.23±1.15) mg/Lvs. (2.92±0.71) mg/L] after treatment for 12 m (all P<0.05).ConclusionLow-dose aspirin combining atorvastatin has better curative effect than only atorvastatin in relieving carotid atherosclerosis and recovering blood fat and hs-CPR in elderly patients with CHD.
Keywords：UltrasoundCarotid arteryAtherosclerosisAtorvastatinAspirin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 63-65 )