Influence of tirofiban combining high-dose atorvastatin on coronary artery flow recovery during emergency percutaneous coronary intervention
CHENG Yun-tao
YANG Guang-xia
LI Chuan-fang
ZHANG Meng
LIU Gen-li
ZHANG Ran
Abstract：Objective To investigate the influence of tirofiban combining high-dose atorvastatin on coronary artery flow recovery during emergency percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).Methods STEMI patients (n=452, male 277, female 175 and aged from 50 to 76) were chosen from Jan. 2013 to Oct. 2014, and then randomly divided into routine group (n=151), tirofiban group (n=151) and combining group (n=150). The routine group was given routine therapy and atorvastatin orally before PCI, tirofiban group was given routine therapy and tirofiban and combining group was given routine therapy, tirofiban and atorvastatin. After PCI for 1 min and 5 min, the coronary artery flow was reviewed with thrombolysis in myocardial infarction (TIMI) grading and TIMI frame count (TFC). All patients were given electrocardiogram (ECG) examination for recording ST-segment elevation degree immediately and 2 h after PCI.Results TIMI grading was improved in combining group compared with routine group and tirofiban group after PCI for 1 min and 5 min (all P<0.05). TFC decreased in combining group compared with routine group and tirofiban group after PCI for 1 min and 5 min [(89.2±13.4)vs. (66.5±8.9)], [(77.8±10.9)vs. (66.5±8.9)], [(62.9±10.1)vs. (49.8±7.5) ], [(55.3±9.1) vs. (49.8±7.5), all P<0.05]. ST-segment resolution was more significant in combining group compared with routine group and tirofiban group immediately and 2 h after PCI [(0.25±0.12) mVvs. (0.32±0.13) mV], [(0.25±0.12) mV vs. (0.27±0.11) mV], [(0.16±0.08) mVvs. (0.20±0.12) mV], [(0.16±0.08) mVvs. (0.18±0.09) mV, all P<0.05]. Conclusion Tirofiban combining high-dose atorvastatin can more effectively improve coronary artery flow than only tirofiban or routine therapy in STEMI patients during PCI.
Keywords：Acute ST-segment elevation myocardial infarctionNo-reflow phenomenonTirofibanAtorvastatin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 43-45,53 )