The best dose of benazepril in treatment of chronic congestive heart failure

doi:10.3969/j.issn.1674-4055.2016.01.10

Abstract：Objective To observe the curative effect of benazepril in different doses in treatment of chronic congestive heart failure (CHF).Methods CHF patients with disease course from 3 y to 15 y (n=240, male 126, female 114, aged from 60 to 81 and average age=73.40±6.35) were chosen from Mar. 2013 to May 2015. The patients were randomly divided into group A (n=76), group B (n=86) and group C (n=78), and the comparison in basic diseases, cause, age, sex and heart function had no statistical difference among 3 groups (all P>0.05). Besides of basic therapy, group A were given benazepril (5 mg, qd), group B, (10 mg, qd) and group C (20 mg, qd). After treatment for 12 m, the curative effect was reviewed and adverse reactions were recorded. The levels of left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDd), left ventricular end-systolic diameter (LVESd), 6-minute walk test (6MWT) and brain natriuretic peptide (BNP) were detected before and after treatment.Results The total effective rate was 80.2% in group A, 87.2% in group B and 96.1% in group C, which was higher in group C than that in group A and group B (all P<0.05). LVEDd, LVESd and LVEF were improved in 3 groups after treatment (all P<0.05). Compared with group A and group B, the improvements of LVEDd, LVESd and LVEF were more significant in group C (all P<0.05). The level of BNP decreased and 6MWT increased in 3 groups after treatment (all P<0.05). The level of BNP decreased and 6MWT increased in group C compared with group A and group B after treatment (all P<0.05). Conclusion Benazepril in dose of 20 mg has higher curative effect than that in dose of 5 mg and that in 10 mg on CHF, and can improve more effectively heart function with higher safety.