Correlation between E-selectin S128R polymorphism and coronary heart disease in Chinese population: a Meta-analysis
HU Long-cai
ZHANG Wei
LI Wei-long
MAO Qiang
Abstract：Objective To study the correlation between E-selectin S128R polymorphism and coronary heart disease (CHD) in Chinese population.Methods The databases of CNKI and PubMed were retrieved for collecting the original case-control studies about the correlation between E-selectin S128R polymorphism and CHD in Chinese population, and eligible studies were enclosed according to internalized standard and the data was merged. The values of OR and 95%CI of E-selectin S128R different genetic models were taken as effective indexes applied in the analysis.Results There were 6 original studies (1788 cases including 938 CHD cases and 850 health controls) included in final data merging. The Meta-analysis on heterozygote comparison model and dominance model showed that the correlation between E-selectin S128R polymorphism and CHD susceptibility had statistical significance (Rvs.S:OR=5.45, 95%CI: 2.69~9.69,P=0.02;RRvs.SS:OR=5.98, 95%CI: 1.32~27.12,P=0.02;RS vs. SS:OR=2.62, 95%CI: 1.94~3.53,P<0.01;RR+RSvs.SS:OR=2.70, 95%CI: 2.01~3.64,P<0.01;RRvs.RS+SS:OR=4.89, 95%CI: 1.07~22.32,P=0.04).Conclusion E-selectin S128R polymorphism is correlated to CHD susceptibility in Chinese population.
Keywords：E-selectinS128R polymorphismCoronary heart diseaseMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 23-25,28 )