Relationship between serum 25 hydroxy vitamin D and carotid atherosclerosis
XUE Jia
ZHANG Wei
SUN Jing
CAO Juan
Abstract：Objective To analyze the correlation between serum 25 hydroxy vitamin D [25(OH)D] and carotid atherosclerosis. Methods The patients (n=100, male 76, female 24 and aged from 39 to 81) were chosen from 2014 to 2015, and then divided into group A (25(OH)D>30 ng/mL, n=9), group B (20 ng/mL<25(OH)D≤30 ng/mL, n=38), group C (15 ng/mL<25(OH)D≤20 ng/mL, n=35) and group D (25(OH)D≤15 ng/mL, n=18). The level of serum 25(OH)D was detected by using double antibody sandwich ELISA, and carotid artery intima-media thickness (CA-IMT) was detected for 3 cardiac cycles. Results Compared with group A, CA-IMT increased in group B, group C and group D [(0.58±0.15) mm vs. (0.75±0.22) mm, (0.58±0.15) mm vs. (0.92±0.24) mm, (0.58±0.15) mm vs. (1.13±0.30) mm, all P<0.05]. 25(OH)D was the independent protective factor of carotid atherosclerosis (OR=0.947, 95%CI:0.907~0.990), and age (OR=1.096, 95%CI:1.009~1.191) and uric acid (OR=1.112, 95%CI:1.007~1.201) were the independent risk factors for carotid atherosclerosis. Pearson correlation analysis showed that CA-IMT was negative related to 25(OH)D (r=-0.49, P<0.05). Conclusion The level of serum 25(OH)D is negatively related to CA-IMT, and is the independent protective factor of carotid atherosclerosis.
Keywords：Carotid atherosclerosis25 Hydroxy vitamin D
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 801-803 )