Short-term curative effect of ticagrelor combining tirofiban during emergency percutaneous coronary ;intervention
ZHOU Song
LI Zhen-lian
WANG Lian-qin
REN Zhen-fang
QI Li-ping
Abstract：Objective To observe the short-term curative effect of ticagrelor combining tirofiban during emergency percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods The patients with STEMI undergone PCI (n=105, male 60, female 45 and average age=57.8±10.1) were chosen from Jun. 2013 to Jun. 2014. All patients were randomly divided into control group (n=50) and test group (n=55), and 2 groups were given ticagrelor and emergency PCI and test group was additionally given tirofiban. TIMI grading, incidence of myocardial perfusion and no reflow after PCI and heart function and LVESd after PCI for 3 m were compared in 2 groups, and major adverse cardiovascular events (MACE) and bleeding events were recorded during hospitalization and after PCI for 3 m. Results Compared with control group, the percentage of patients with grade 3 of TIMI and percentage of patients with ST-segment resolution>75%increased, and percentage of patients with no reflow decreased in test group after PCI [(78.0%vs. 92.7%), (50.0%vs. 78.2%), (16.0%vs. 1.8%), all P<0.05]. There were 3 patients (6.0%) with serious bleeding, 3 (6.0%) with hyporrhea and 44 (88.0%) with mild bleeding in control group, and there were 1 patient (1.8%) with serious bleeding, 11 (20.0%) with hyporrhea and 43 (78.2%) with mild bleeding in test group (P>0.05). The incidence of MACE decreased, LVESd decreased and LVEF increased [(3.6%vs. 18%), (46.5±4.7) mm vs. (48.8±5.7mm), (57.9±5.1)%vs. (55.1±6.1)%)] in test group compared with control group within 3 m after disease attack (all P<0.05). Conclusion Ticagrelor combining tirofiban is better than only ticagrelor therapy in improving myocardial perfusion, protecting heart function and non-increasing bleeding risk in patients with acute myocardial infarction undergone PCI.
Keywords：TicagrelorTirofibanPercutaneous coronary interventionMyocardial perfusion
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 798-800,803 )