Detective value of high sensitive cardiac troponin T in patients with coronary borderline lesion during ;percutaneous coronary intervention under pressure wire guide
ZHANG Jing
HE Sheng-hu
XU Ri-xin
CHEN Shu
XIE Yong
LIU Xiao-dong
JI Jun
LIAO Qing-chi
XU Bin
WANG Xue-fei
KONG Ling-cai
Abstract：Objective To investigate the detective value of high sensitive cardiac troponin T (hs-cTnT) in patients with coronary borderline lesion during percutaneous coronary intervention (PCI) under pressure wire guide. Methods The patients with coronary heart disease (CHD, n=86) were chosen from Jan. 2012 to Jun. 2014 [including 32 with stable angina pectoris (SAP) and 54 unstable angina pectoris (UAP)]. All patients were given detection of hs-cTnT and coronary angiography (CAG) for diagnosing with at least 1 coronary artery stenosis (from 40%to 70%) before PCI, and then given pressure wire for detecting fractional flow reserve (FFR). The patients were divided into control group (FFR>0.75 and treated with conservative drug therapy) and PCI group (FFR<0.75 and treated with PCI) according to FFR values. PCI group was divided again into higher hs-cTnT group (≥0.034 ng/mL) and normal hs-cTnT group (<0.034 ng/mL). The numbers of disease vessels and stents were counted in PCI group, and incidence of major adverse cardiac events (MACE) including angina pectoris (AP), nonfatal myocardial infarction (MI), sudden cardiac death and target vessel revascularization (TVR) were compared in 3 groups during hospitalization and follow-up period. Results Compared with normal hs-cTnT group, the number of disease coronary arteries (46.90%vs. 33.30%) and average stenting number (1.8 vs. 1.1) increased in higher hs-cTnT group (P<0.05). The incidence of MACE was significantly higher in higher hs-cTnT group (0.526±0.088 ng/mL) than that in normal hs-cTnT group and control group (P<0.05), while the comparison between normal hs-cTnT group (0.019±0.011 ng/mL) and control group had no significant difference. Conclusion The detection of hs-cTnT combining FFR can direct the treatment of coronary borderline lesion during PCI, and predict the incidence of MACE.
Keywords：Fractional flow reserveHigh sensitive cardiac troponin TCoronary borderline lesionAdverse cardiac events
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 770-772 )