Myocardial protective effects of once atorvastatin in different load doses in patients with stable angina ;pectoris before percutaneous coronary intervention
ZHOU Quan
HUANG Yi
XU Xiao-xuan
ZHANG Zhi-xiang
GUO Ning
LUO Li
Abstract：Objective To investigate the influence of once atorvastatin in different load doses on myocardium in patients with stable angina pectoris (SAP) before percutaneous coronary intervention (PCI). Methods SAP patients with selected PCI (n=106, male 72, female 34 and aged from 42 to 78) were chosen from Jun. 2013 to Dec. 2014, and randomly divided into group A (n=35), group B (n=35) and group C (n=36). All groups were given atorvastatin orally 8-12 h before PCI (group A: 20 mg, group B: 40 mg and group C: 80 mg). The changes of creatine kinase MB (CK-MB), cardiac troponin T (cTnT), high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) were detected in 3 groups before and 8 h and 24 h after PCI. Results The levels of CK-MB, cTnT and hs-CRP increased in group A 8 h and 24 h after PCI, and increased in group B and group C 24 h after PCI (all P<0.05). Compared with group A, the levels of CK-MB and cTnT decreased in group B and group C 24 h after PCI (all P<0.05). Compared with group B, the levels of CK-MB, cTnT and hs-CRP decreased in group C 24 h after PCI (all P<0.05). The change of level of ALT was not significant in 3 groups (all P>0.05). Conclusion For SAP patients without taking statins for long time, atorvastatin in dose of 80 mg given before PCI has better myocardial protective effect than that in dose of 20 mg or in dose of 40 mg.
Keywords：Coronary heart diseaseAtorvastatinPercutaneous coronary interventionCardiac troponin T
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 767-769 )