Influence of ticagrelor and clopidogrel on platelet function and inflammatory factors in patients with acute ;coronary syndrome after percutaneous coronary intervention
GAO Peng
ZHONG Ning
CHANG Jun-yi
Abstract：Objective To compare the influence of ticagrelor and clopidogrel on platelet function and inflammatory factors in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods ACS patients diagnosed by coronary angiography (n=84, male 52, female 32, aged from 50 to 71 and average age=60.48±8.96) were chosen from Jan. 2013 to Feb. 2014, and then divided randomly into ticagrelor group and clopidogrel group (each n=42). The ticagrelor group was given anti-platelet treatment with aspirin+ticagrelor and clopidogrel group, with aspirin+clopidogrel for 12 m. The changes of maximum platelet aggregation rate (MPAR), P2Y12 reaction unit (PRU), sCD40L and high sensitivity C-reactive protein (hs-CRP) were detected before, 24 h, 7 d and 28 d after PCI. The adverse reactions were monitored, and ischemic and bleeding events were followed up for 12 m. Results MPAR and PRU were significantly lower in ticagrelor group than those in clopidogrel group 24 h, 7 d and 28 d after PCI (all P<0.01). The levels of inflammatory factors reached the peak 24 h after PCI and then decreased in 2 groups. The levels of hs-CRP and sCD40L were lower in ticagrelor group than those in clopidogrel group 24 h, 7 d and 28 d after PCI (all P<0.05). During 12-m follow-up period, the incidence of ischemic events was lower in ticagrelor group than that in clopidogrel group (2.38%vs. 19.05%, P<0.05). Conclusion Ticagrelor is better than clopidogrel in anti-platelet aggregation and relieving inflammatory reactions, and it can reduce the incidence of ischemic events in ACS patients after PCI.
Keywords：Acute coronary syndromeInflammatory factorsTicagrelorClopidogrel
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 763-766,769 )