Relationship between homocysteine and coronary heart disease
ZHAO Guo-zhong
WANG Hua
HE Min
CHEN Chen
WANG Lan-lin
Abstract：Objective To analyze the relationship between homocysteine (Hcy) and coronary heart disease (CHD). Methods CHD patients (n=120, male 63, female 7 and average age=52.8±10.1) undergone coronary angiography (CAG) were chosen from Jan. 2011 to Dec. 2014. All patients were divided into test group (n=92, with at least 1 coronary artery stenosis≥50%among 3 coronary arteries) and control group (n=28, with all 3 coronary artery stenosis<50%). The test group was divided, according to clinical types, into stable angina pectoris group (SAP group, n=26), unstable stable angina pectoris group (UAP group, n=31) and acute myocardial infarction group (AMI group, n=35), and divided, according to Syntax scores, into low-risk group (0-22 scores, n=18), mid-risk group (23-32 scores, n=29) and high-risk group (over 33 scores, n=45). The level of Hcy was detected in all groups. Results Compared with control group, the level of Hcy increased [(10.93±2.51)μmol/L vs. (21.93±5.54)μmol/L] and percentage of patients with hyperhomocysteinemia increased (14.28%vs. 51.08%) in test group (all P<0.05). The level of Hcy had a increasing trend in SAP group, UAP group and AMI group, and was significantly higher in UAP group and AMI group than that in control group [(17.85±5.67)μmol/L vs. (10.93±2.51)μmol/L, (24.56 ±5.03)μmol/L vs. (10.93±2.51)μmol/L, all P<0.05]. The level of Hcy was higher in low-risk group, mid-risk group and high-risk group than that in control group (P<0.05). Conclusion The level of Hcy is closely related to the occurrence and severity of CHD, and detection of Hcy is significant to preventing CHD.
Keywords：HomocysteineCoronary angiographyCoronary heart diseaseSyntax score
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 758-759,762 )