Clinical effect of rosuvastatin and nicorandil in patients with coronary slow flow
Sun Qi
Zhang Jian
LV Xiao-yan
Shi Yu-jie
Li Jun-xia
Abstract：Objective To study the therapeutic effect of rosuvastatin and nicorandil in patients with coronary slow flow. Methods A total of 50 patients with coronary slow flow and chest pain were randomly divided into 2 groups. The statin group(n=24) were treated with rosuvastatin 10mg Qn. The combined therapy group(n=26) were treated with rosuvastatin 10mg Qn and nicorandil 5mg tid. All patients were treated for 6 months. After 6 months, the coronary flow velocity in all three coronaries were measured by angiograph. TC, TG, LDL, HDL, hs-CRP, ET-1, NO were detected before and after treatment. Results: 6 months later, the coronary flow velocity in all three coronaries of both statin group and combined therapy group was significantly improved(P<0.05). The combined therapy group improved more significantly than the statin group(P<0.05). Compared with 6 months before in the same group, the level of TC, TG, LDL, hs-CRP and ET-1(P<0.05).But the level of NO(P<0.05);Compared with statin group 6 months later, there were no significant difference among TC, TG and LDL. While the level of hs-CRP and ET-1 were decreased significantly(P<0.05),and the level of NO was elevated significantly(P<0.05). Conclusions:Combination of rosuvastatin and nicorandil can both inhibit the inflammatory response and improve the endothelial function. Then it was effective to the patients with coronary slow flow. The efficacy of combined therapy was superior to the statin alone.
Keywords：coronary slow flowrosuvastatinnicorandil
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 748-750 )