Relationship among serum copeptin level, blood pressure and related risk factors in young university ;students

TANG Qun; XU Bo; TIAN Jian-wei; WANG Xin-yan; WANG An-qi; HUANG Cui-ying; ZANG Chun-mei

doi:10.3969/j.issn.1674-4055.2015.06.06

Abstract：Objective To investigate the relationship among serum copeptin level, central systolic blood pressure (CSBP) and related risk factors in young university students. Methods The students of Xi’an Technological University were chosen including 172 cases of hypertension and 198 cases of normal blood pressure (BP). The indexes of CSBP, peripheral BP [systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP)], arm circumference, height and weight were detected and BMI was calculated, and levels of copeptin, angiotensin II (Ang II), aldosterone (ALD), nitric oxide (NO), triglyceride (TG), cholesterol (CH), creatinine (Cr), blood urea nitrogen (BUN) and plasma glucose were detected. The correlation among copeptin, BP and related risk factors was analyzed. Results CSBP was positively related to SBP, DBP and MAP (r=0.940, r=0.834, r=0.901, P<0.01) in young university students. As the increase of copeptin level, SBP, DBP, MAP and CSBP increased gradually (P<0.01). Copeptin level was positively related to CSBP, SBP, DBP, MAP, BMI, Ang II and ALD (r=0.136, r=0.138, r=0.170, r=0.155, r=0.137, r=0.153, r=0.220, P<0.05), and negatively related to NO (r=-0.117, P<0.05). Multiple linear regression analysis showed that DBP ascending trend still existed as the increases of copeptin level after regulating age, sex, weight, BMI, plasma glucose and CH (β=1.219, P=0.041). SBP, MAP and CSBP were mainly correlated to BMI, plasma glucose and CH (P<0.05). Conclusion The level of serum copeptin is not only related to CSBP and peripheral BP, but also correlated to BMI, plasma glucose and CH.