Relationship between serum LP(a) level and severity of coronary lesion in patients with acute coronary ;syndrome complicating diabetes
WANG Gang
GUO Yi-feng
JIN Feng-lin
LIU Peng
ZHAO Yang
ZHANG Bin
Abstract：Objective To discuss the relationship between the level of serum lipoprotein [LP(a)] and severity of coronary lesion in patients with acute coronary syndrome (ACS) complicating diabetes. Methods ACS patients (n=168) were divided, according to the level of fasting plasma glucose (FPG), into group A (single ACS, FPG<6.1mmol/L, n=52), group B (ACS complicating increased blood sugar, 6.1 mmol/L≤FPG<7.1 mmol/L, n=56) and group C (ACS complicating diabetes, FPG≥7.1 mmol/L, n=58), and other 50 health controls were chosen as control group. The levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), LP(a), C-reactive protein (CRP), creatine kinase (CK) and creatine kinase MB (CK-MB) were detected respectively in all groups. At the same time the number of diseased coronary vessels and severity (Gensini score) were detected by using coronary angiography (CAG). Results The levels of SBP, DBP, TC, TG, LDL-C, LP(a), CRP, CK and CK-MB were higher, and level of HDL-C was lower in group A, group B and group C than those in control group (P<0.05). The levels of FPG, TG, LP(a), CRP, CK and CK-MB were significantly higher (P<0.05), and level of HDL-C was lower (P<0.05) in group C than those in group A and group B. The levels of LP(a) and CRP were higher in group B than those in group A (P<0.05). As the increase of diseased coronary arteries, Gensini scores and LP(a) level increased significantly in ACS patients. Pearson correlation analysis showed that FPG, TG, LDL-C, LP(a), CRP, CK and CK-MB were positively related to Gensini scores (P<0.05). Logistic multi-factor analysis showed that TG, LP(a), CRP and CK were independent risk factors of Gensini scores for patients with ACS complication diabetes. Conclusion The level of serum LP(a) is significantly higher in patients with ACS complication diabetes than in those without complication diabetes, and LP(a) is related to the severity of coronary artery lesion of ACS.
Keywords：Acute coronary syndromeDiabetesSeverity of coronary lesionSerum lipoprotein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 737-739,743 )