Relationship between hyperuricemia and carotid atherosclerosis
XUE Jia
ZHANG Wei
SUN Jing
CAO Juan
Abstract：Objective To study the relationship between hyperuricemia and carotid atherosclerosis, and provide the evidence for treating and preventing hyperuricemia.Methods The patients with carotid atherosclerosis confirmed by vessel ultrasound examination were chosen as atherosclerosis group (n=110, male 105, female 5 and average age=61.3±11.8) from Jan. 2012 to Jan 2014. In atherosclerosis group, there were 92 patients diagnosed with hyperuricemia set into combined group. The healthy volunteers were chosen as health group (n=110, male 104, female 6 and average age=61.9±12.3). The relationship among hypertension, hyperuricemia and carotid atherosclerosis were analyzed by using Pearson single factor analysis and multiple Logistic regression analysis. The changes of serum uric acid (SUA) and C-reactive protein (CRP) were compared between combined group and healthy group.Resutls The cases of hyperuricemia (n=92) were significantly more in atherosclerosis group than those in health group (n=31). Pearson single factor analysis showed that diabetes, hyperlipidemia, hypertension and hyperuricemia were risk factors of carotid atherosclerosis. The levels of SUA and CRP were significantly higher in combined group than those in health group (P<0.05).Conclusion Hyperuricemia is an independent risk factor inducing carotid atherosclerosis. Because the factors of hyperuricemia inducing atherosclerosis include vessel lesions, inflammation and uric acid crystal, definitive therapy is necessary for treating and preventing carotid atherosclerosis.
Keywords：HyperuricemiaCarotid atherosclerosisCorrelation analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 684-686 )