Influence of fluoroquinolones on sudden death in patients with diagnosed high risk heart disease
WANG Xing-yuan
YANG Shan-jin
FAN Li-juan
ZHOU Hong-xia
CAO Hong-bing
Abstract：Objective To study the influence of fluoroquinolones (FLQs) on sudden death in patients with diagnosed high risk heart disease.Methods The patients (n=518, male 213, female 305 and aged from 45 to 88) were chosen from Jan. 1999 to Jan. 2010. All patients were divided, according to whether or not using FLQs, into FLQs group (n=78) and control group (n=440). The patients with malignant arrhythmia confirmed by Holter were followed up and surveyed, and the causes of death and incidence of sudden death were investigated.Results Of 78 patients in FLQs group, 42 died including 26 of sudden death, and of 440 patients in control group, 124 died including 22 of sudden death. In FLQs group, 2 patients were successfully resuscitated after sudden death, but finally died due to multiple organ failure and they were classified to sudden death patients. The incidence of sudden death was significantly higher in FLQs group than that in control group (33.3%vs. 5.0%,P<0.01).Conclusion When the patients with high-risk heart disease use FLQs, the incidence of sudden death will be increased.
Keywords：FluoroquinolonesSudden deathHigh risk heart disease
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 682-683,686 )