Curative effect of trimetazidine during percutaneous coronary intervention in patients with unstable angina pectoris

ZHOU Wei-wei; ZHAO Bing; LIU Shu-man; YANG Chun-xia

doi:10.3969/j.issn.1674-4055.2015.05.25

Abstract：Objective To review the influence of trimetazidine during percutaneous coronary intervention (PCI) in patients with unstable angina pectoris (UAP).Methods UAP patients (n=79, male 52, female 27 and average age=59.3±9.4) were chosen from Dec. 2013 to Nov. 2014. The patients were randomly divided into routine group (n=40) and trimetazidine group (n=39). The routine group was treated with aspirin, clopidogrel and statins, and trimetazidine group additionally with trimetazidine orally (20 mg, 3 times a day) 3 d before PCI and continuously after PCI. The changes of creatine kinase (CK), creatine kinase MB (CK-MB) and cardiac troponin T (cTnT) were detected in all patients before and 24 h after PCI. The curative effects were compared between 2 groups, and improvement of coronary artery flow was reviewed by using TIMI frame count (TFC).Results The levels of CK, CK-MB and cTnT increased in routine group after PCI (allP<0.05). Compared with routine group after PCI, the levels of CK [(102.52±30.40) U/Lvs. (82.37±22.40) U/L], CK-MB [(19.52±3.49) U/Lvs. (14.37±2.68) U/L] and cTnT [(0.13±0.12) ng/mLvs. (0.05±0.08) ng/mL] decreased in trimetazidine group (allP<0.05). There were 16 cases (40%) with obvious curative effect, 14 (35%) with curative effect and the total effective rate was 75.0% in routine group. There were 26 cases (66.7%) with obvious curative effect, 9 (23.1%) with curative effect and the total effective rate was 89.7% in trimetazidine group (P<0.05). The average TFC values of anterior descending branch and circumflex branch or coronary artery were significantly lower in trimetazidine group than those in routine group (allP<0.05).Conclusion Trimetazidine can inhibit perioperative myocardial injury correlated to PCI, and improve coronary flow reserve.