Comparison in curative effects of second-generation drug-eluting stent in treatment of focal-type and non-focal-type in-stent restenosis
ZHANG Hui-fang
SONG Hong-yong
ZHAO Lin
ZHOU Jian-jun
GUO Cheng-jun
Abstract：Objective To compared the clinical outcomes of focal-type in-stent restenosis (ISR) and non-focal-type ISR treated with second-generation drug-eluting stent (DES).Methods The patients (n=254, male 201 and female 53) undergone second-generation DES due to DES-ISR were chosen from Jan. 2011 to Mar. 2013. All patients were divided into focal-type ISR group (n=87) and non-focal-type ISR group (n=167) according to the outcomes of angiography. The patients were followed up for 2 y, the incidence of major adverse cardiovascular events [MACE, including cardiac death, myocardial infarction and target lesion revascularization (TLR)] were compared in 2 groups, and risk factors of TLR were analyzed after treatment.Results The percentage of patients with B2/C lesion was significantly higher (69.5%vs. 41.4%), and lesion duration [(25.46±3.38) mmvs. (8.13±2.21) mm] and stent length [(28.59±11.25) mmvs. (19.47±7.09) mm] were higher in non-focal-type ISR group than those in focal-type ISR group (allP<0.01). The incidence of MACE (38.3% vs. 24.1%) was significantly higher and TLR (32.3%vs. 18.4%) was significantly higher in non-focal-type ISR group than those in focal-type ISR group (allP<0.01). COX regression analysis showed that non-focal-type ISR was an independent risk factor of TLR (OR=2.134, 95%CI: 1.173-3.884). Kapan-Meier survival curve showed that the survival rate of TLR was higher in focal-type ISR group than that in non-focal-type ISR group within 2 y after undergone second-generation DES (P=0.024).Conclusion When applying second-generation DES for treating DES-ISR, the prognosis is better in patients with focal-type ISR than that in patients with non-focal-type ISR.
Keywords：Second-generation drug-eluting stentIn-stent restenosisFocal-typeNon-focal-typeTarget lesion revascularization
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 659-662 )