Preventive effect of alprostadil on contrast-induced nephropathy in patients with coronary heart disease complicating diabetes undergone percutaneous coronary intervention
SUN Xiao-xia
WANG A-li
ZUO Hong
QIN Li-ming
Abstract：Objective To investigate the effect of alprostadil in preventing contrast-induced nephropathy (CIN) in patients with coronary heart disease (CHD) complicating diabetes undergone percutaneous coronary intervention (PCI).Methods The patients (n=86, male 45, female 41 and average age=60.3±14.3) were chosen from Jun. 2008 to Jan. 2014. All patients had renal injury in varying degrees, and divided randomly into observation group (n=43, male 23, female 20 and average age=61.2±13.7) and control group (n=43, male 22, female 21 and average age=59.4±14.9). The control group was given anti-hyperlipidemia, anti-platelet aggregation and hydration therapies, and observation group was additionally given intravenous drip of alprostadil (10 μg, diluted with normal saline solution) 30 min before coronary angiography (CAG) and given venous injection 3 d after PCI. The kidney function and incidence of CIN were compared in 2 groups.Results The difference in blood urea nitrogen (BUN), serum creatinine (Scr) and glomerular filtration rate (GFR) had no statistical significance between 2 groups before PCI (P>0.05). After PCI for 24 h, the difference in GFR had statistical significance (P<0.05), and difference in BUN, Scr and GFR had statistical significance (P<0.05) after PCI for 72 h in 2 groups. The difference in rate of hematodialysis, hospitalization days and residence of CIN had statistical significance (P<0.05) between 2 groups. Conclusion Alprostadil can significantly prevent the occurrence of CIN, improve kidney function, and reduce rate of hematodialysis and hospitalization days in patients with CHD complicating diabetes.
Keywords：Contrast-induced nephropathyIntervention therapy for coronary heart diseaseDiabetesAlprostadil
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 647-649 )