Influence of multiple blockers combination on ventricular remodeling and QT dispersion in patients with dilated cardiomyopathy and heart failure
WANG Li-juan
BAI Hong-xing
Abstract：Objective To investigate the influence of multiple blockers combination on ventricular remodeling and QT dispersion (QTd) in patients with dilated cardiomyopathy (DCM) and heart failure (HF).Methods The patients (n=80) were chosen from Mar. 2011 to Dec. 2014, and randomly divided into treatment group (n=40, male 21, female 19 and average age=56.87±4.11) and control group (n=40, male 19, female 21 average age=56.98±3.89). The control group was treated with anti-HF drugs and treatment group was additionally treated with spironolactone and metoprolol for 14 d.Results The effective rate was 80.0% in control group and 97.5% in treatment group (P<0.05) after treatment for 14 d. LVEDD and LVESD decreased significantly and LVEF increased significantly in 2 groups after treatment (P<0.05). LVEDD, LVESD and LVEF had statistical difference between 2 groups (P<0.05). QTd had a significant descending trend in 2 groups after treatment (P<0.05), and was lower significantly in treatment group than that in control group (P<0.05).Conclusion The combining administration of multiple blockers can effectively reverse ventricular remodeling, shorten QTd and improve the total curative effect in patients with DCM and HF.
Keywords：Dilated cardiomyopathyVentricular remodelingQT dispersionSpironolactoneMetoprolol
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 644-646 )