Influence of Danhong Injection combining external counterpulsation on inflammatory factors in patients with acute coronary syndrome after percutaneous coronary intervention
GUO Lin-lin
AN Yi
SUN Bing
CHU Xian-ming
LI Tian-dong
Abstract：Objective To investigate the influence of Danhong Injection combining external counterpulsation (ECP) on inflammatory factors in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods The patients (n=118, male 68 and female 50) were chosen from Nov. 2012 to Aug. 2014, and divided randomly into group I (n=38), group II (n=40) and group III (n=40). All groups were given routine treatment (including aspirin, clopidogrel, statins, ACEI, ARB, β-receptor blockers, nitrates and low molecular weight heparin). Group I was given routine treatment only, group II was additionally given 0.9% sodium chloride injection (250 mL) or 5% glucose (250 mL) and Danhong Injection (40 mL), and group III was additionally given 0.9%sodium chloride injection (250 mL) or 5% glucose (250 mL) and Danhong Injection (40 mL) and ECP (1 h/time, 1 time/d) for 14 d. The levels of high-sensitivity C-reactive protein (hs-CRP), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were detected 1 d before PCI, 1 d after PCI (24 h± 2 h) and after PCI for 14 d.Results There were 2 patients in group I, 1 in group II and 3 in group III dropped out from the study because they cannot bear ECP or their disease exacerbated. The levels of hs-CRP, ICAM-1 and VCAM-1 increased in 3 groups 1 d after PCI compared with those 1 d before PCI (P<0.05). The levels of hs-CRP, ICAM-1 and VCAM-1 decreased in group II and group III compared with group I after treatment for 14 d (P<0.05), and decreased in group III compared with group II (P<0.05).Conclusion Danhong Injection combining ECP can reduce the levels of inflammatory factors in patients with ACS after PCI.
Keywords：Danhong InjectionExternal counterpulsationAcute coronary syndromeHigh-sensitivity C-reactive proteinIntercellular adhesion molecule-1Vascular cell adhesion molecule-1
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 631-634 )