Influence of trimetazidine in patients with acute myocardial infarction undergone percutaneous coronary intervention
WANG Ting
LI Jie-hua
Abstract：Objective To discuss the influence of trimetazidine in patients with acute myocardial infarction (AMI) undergone percutaneous coronary intervention (PCI).Methods The patients (n=70, male 53, female 17, aged from 48 to 76, and average age=60.84±6.89) with selected PCI were chosen from Jul. 2013 to Jul. 2014, and randomly divided into trimetazidine group and control group (eachn=35). The control group was given routine treatment and trimetazidine group was additionally given trimetazidine in load dose (60 mg) 30 min before PCI and continuously after PCI. The changes of ST-segment, LVEF, CK-MB, cTnI were compared in 2 groups after PCI.Results The descend range of ST-segment was more significant in trimetazidine group than that in control group [(7.48±9.12) mmvs. (3.64 ±0.81) mm,P<0.01]. Compared with control group, the percentage of cases with descend range of ST-segment over 70% increased in trimetazidine group (42.86%vs. 80.00%,P<0.01). LVEF increased in 2 groups (allP<0.05), and was higher in trimetazidine group than that in control group after treatment (allP<0.05). The peak concentration of CK-MB [(125.00±31.5) U/Lvs. (166.56±22.13) U/L] or cTnI [(1.63±0.44) ng/Lvs. (2.155±0.50) ng/L] was lower in trimetazidine group than that in control group (allP<0.01).Conclusion Trimetazidine can improve heart function and relieve myocardial ischemia and injury in AMI patients undergone PCI.
Keywords：TrimetazidineAcute myocardial infarctionIntervention therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 619-621 )