Research on serum renin in patients with primary hypertension

WANG Shu-qi; LIU Li-qiu; WANG Ke; WANG Shu-juan; LIU Hai-na; LI Xiao-hong

doi:10.3969/j.1674-4055.2015.04.38

Abstract：Objective To discuss the distribution of serum level of renin in patients with primary hypertension. Methods The patients with primary hypertension without drug treatment (n=130, male 100, female 30 and average age=47.32±10.26) were chosen as hypertension group, and other healthy controls (n=20 male 16, female 4 and average age=44.85±8.18) were chosen as control group from Jun. 2013 to Jul. 2014. The serum level of renin was detected in all subjects. All subjects were divided into groups according to hypertension grading criterion, ages and body mass index (BMI), and renin level was compared. Results The serum level of renin was significantly lower in hypertension group than that in control group [(82.13±42.) mIU/mL vs. (130.26±54.7) mIU/mL, P<0.01], and decreased in groups of hypertension grade 2 and hypertension grade 3 compared with control group and group of hypertension grade 1 (P<0.05). The patients were divided, according to age, into age<40 group, age=40~49 group, age=50~59 group and age≥60 group, and the serum level of renin decreased in a descending order, but the difference had no statistical significance among groups (all P>0.05). The patients were divided, according to BMI, into BMI<24 kg/m2 group, BMI=24-28 kg/m2 group and BMI>28 kg/m2, and the comparison showed that mean difference had no statistical significance among groups (all P>0.05). Conclusion The serum level of renin decreases in patients with primary hypertension compared with healthy controls, while renin may participate the onset mechanism of hypertension.