Influence of exercise intervention on oxidative stress and glucose metabolism in patients with hypertension accompanied by pre-diabetes
MA Li-qing
PAN Wei-wei
DING Hua-min
Abstract：Objective To observe the influence of exercise intervention on oxidative stress and glucose metabolism in patients with hypertension accompanied by pre-diabetes. Methods The patients (n=69) were chosen and divided randomly into intervention group and control group. The intervention group was given 6-m systematical exercise intervention besides of routine drug therapy and control group was given routine drug therapy besides of keeping peaceful lifestyle. The changes of body mass index (BMI), blood pressure (BP), serum malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO) and plasma glucose were observed in 2 groups. Results After 6 m, BMI [(21.3±5.6) kg/m2 vs. (24.8±6.1) kg/m2], systolic blood pressure [(135.9 ±6.7) mmHg vs. (142.1 ±5.2) mmHg] (1 mmHg=0.133kPa) and diastolic blood pressure [ (81.7±6.2) mm Hg vs. (85.1±4.9) mmHg] decreased, MDA [(7.46±1.5)μmol/L vs. (8.24±1.3)μmol/L] decreased, SOD [(98.72±10.8) U/ml vs.(87.05 ±14.2) U/ml] and NO [(81.65±14.2)μmol/L vs. (71.82±13.3)μmol/L] increased, fasting plasma glucose [(4.87 ±1.92) mmol/L vs. (6.54±2.48) mmol/L], 2-hour postprandial blood glucose [(7.63±3.72) mmol/L vs. (9.73±2.63) mmol/L] and glycated hemoglobin [(4.78±2.54)%vs. (6.12±1.68)%] decreased in intervention group compared with control group (all P<0.05). Conclusion Exercise intervention can reduce BMI and BP, relieve abnormal oxidative stress and glucose metabolism, and delay and prevent diabetes in patients with hypertension accompanied by pre-diabetes.
Keywords：HypertensionPre-diabetesExercise interventionOxidative stress
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 539-541 )