Different curative effect of spironolactone in patients with refractory hypertension at different age stages
GAI Yan-hong
LUAN Xiao-dong
ZHU Wei-yong
XU Dan
Abstract：Objective To discuss the difference in curative effect of spironolactone in patients with refractory hypertension at different age stages. Methods The patients (n=144, male 75, female 69, aged from 53 to 78 and average age=615±97) were chosen from Sept. 2012 to May 2014. The patients were divided, according to registration order, into spironolactone group (n=71) and control group (n=73) by using random digital table, and according to age, into age≤60 group (n=72) and age>60 group (n=72). The spironolactone group was additionally given spironolactone and control group was additionally given placebo on the base of original treatment for 12 w. The blood pressure monitor was used for monitoring 24-h ambulatory blood pressure, and after monitoring daytime average systolic blood pressure (SBP), daytime average diastolic blood pressure (DBP) and daytime average pulse pressure (PP), nighttime average SBP, nighttime average DBP and nighttime average PP, and 24-h average SBP, 24-h average DBP and 24-h average PP were calculated. Results The daytime average SBP, nighttime average SBP, 24-h average SBP, clinic SBP, nighttime average PP and 24-h average PP decreased significantly in age>60 group compared with age≤60 group (all P<0.05). For patients aged>60, daytime average SBP, nighttime average SBP, 24-h average SBP, clinic SBP, daytime average PP, nighttime average PP and 24-h average PP decreased significantly in spironolactone group compared with control group (all P<0.05). Conclusion Spironolactone can reduce SBP in patients with refractory hypertension.
Keywords：Refractory hypertensionSpironolactoneBlood pressureSystolic blood pressureAge
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 537-538,541 )