Curative effect and safety of ticagrelor administrated in emergency percutaneous coronary intervention
HOU Fang-jie
XING Ming-qing
WANG Yan-ping
WU Na
YAN Rong-qiang
REN Yong-qiang
MA Ying
WANG Hai-yang
SHI Yue
WANG Zheng-zhong
YU Zhong-xiang
LIN Xian-ru
GUAN Jun
Abstract：Objective To discuss the curative effect and safety of ticagrelor administrated in emergency percutaneous coronary intervention (PCI). Methods The patients (n=192) with acute myocardial infarction (AMI) undergone emergency PCI were chosen from Jan. 2013 to Mar. 2014, and randomly divided into ticagrelor group (n=105) and clopidogrel group (n=87). The clinical data of patients were analyzed statistically. The incidence of major adverse cardiovascular and cerebrovascular events (MACCE, including unstable angina pectoris, myocardial infarction and death), bleeding and dyspnea were compared between 2 groups during hospital stay and after follow-up for 3 m. Results The general conditions had no statistical difference between 2 groups (P>0.05). After follow-up for 3 m, the incidence of MACCE was significantly lower in ticagrelor group than that in clopidogrel group (P<0.05), and incidence of bleeding had no statistical difference between 2 groups (P>0.05). There were 6 cases with recurrent acute coronary syndrome (ACS) in clopidogrel group, and then they were given secondary PCI and ticagrelor replacing clopidogrel (preoperative dose of 180 mg and 90 mg three times a day after PCI). These patients were given thrombelastogram examination before and 24 h after PCI, and the outcomes showed that ADP inhibitory rate and ADP-induced platelet-fibrin clot strength (MAADP) were all higher after ticagrelor administration (P<0.05). Conclusion Ticagrelor has higher curative effect and safety than clopidogrel in population undergone emergency PCI.
Keywords：TicagrelorEmergency percutaneous coronary interventionAcute myocardial infarction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 533-536 )