Curative effect of Zhikang Granules combining fenofibrate in patients with hyperlipidemia
HE Hai-zhou
LI Bo-ying
Abstract：Objective To investigate the clinical efficacy and safety of Zhikang Granules combining fenofibrate in patients with hyperlipidemia. Methods The patients (n=76) were randomly divided into test group and control group. The test group was given Zhikang Granules (8 g twice a day) combining fenofibrate (200 mg once a day) and control group was given fenofibrate (200 mg once a day) and placebo (8 g twice a day) for 8 w. The changes of blood fat, total effective rate and adverse reactions were observed in 2 groups. Results The decrease degree of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) was higher (P<0.05) and increase degree of high-density lipoprotein-cholesterol (HDL-C) was higher (P<0.05) in test group than those in control group. The total effective rate was 92.3%in test group and 75.7%in control group (P<0.05). After treatment, ALT and AST decreased significantly in test group (P<0.05) and had no significant changes in control group (P>0.05). Conclusion Zhikang Granules combining fenofibrate has not only cooperative effect of reducing blood fat, but also curative effect of protecting liver and lowering transaminase in the treatment of hypertension.
Keywords：Zhikang GranulesFenofibrateHyperlipidemia
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 530-532 )