Influence of preoperative tirofiban administration on inflammatory reactions in patients with of middle-high risk non-ST-segment elevation acute coronary system
LUO Ya-wei
CHEN Fang
ZHANG Wei-dong
GAO Yue-chun
ZHANG Xiao-ling
ZHANG Yu-chen
PAN Yu
HE Ji-qiang
Abstract：Objective To observe the influence of preoperative tirofiban administration on the inflammatory reactions in patients with middle-high risk of non-ST-segment elevation acute coronary system (NSTEACS). Methods The patients (n=80 and aged from 18 to 75) planed to have percutaneous coronary intervention (PCI) were chosen from May 2009 to Jul. 2010, and divided into 2 groups. The pre-PCI group (n=38) was given tirofiban in loading dose (10 g/kg injected within 3 min) at first and (12±2) h before coronary angiography and then given intravenous drip of tirofiban (0.15 g/kg/min) for 24 h after PCI. The control group (n=42) was given tirofiban in loading dose (10 g/kg injected within 3 min) after guiding catheter placed and then given intravenous drip of tirofiban (0.15 g/kg/min) for 24 h after PCI. The incidence of major adverse cardiovascular events (MACE) was compared between 2 group during hospital stay and 30 d after discharge. The levels of high-sensitivity C-reactive protein (hs-CRP), soluble CD40 ligand (sCD40L), cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) were detected befor and after PCI. Results In pre-PCI group, the levels of CK-MB, hs-CRP and sCDL40 decreased after PCI [(22.91±11.76) U/L vs. (14.69±15.72) U/L], [(16.50±7.76) mg/L vs. (10.91±13.16) mg/L], [(18.92± 8.90) g/L vs. (12.65±10.99) g/L, all P<0.05]. Compared with control group, sCDL40 decreased in pre-PCI group after PCI [(14.23±8.91) g/L vs. (12.65±10.99) g/L, P<0.05]. The difference in incidence of endpoint events had no statistical significance (P=0.860) between 2 groups. Conclusion The early administration of tirofiban before PCI can inhibit the inflammatory reactions and relieve acute myocardial impairment.
Keywords：Myocardial infarctionTirofibanMyocardial perfusionPercutaneous coronary intervention
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 524-526 )