Influence of irbesartan on heart rate variability in elderly patients with congestive heart failure
HUO Gang
LI Wen-jun
SU Hua-ke
ZHAO Sheng-jia
LIN Yan-fei
TIAN Jia-xin
HAO Yong-zhe
Abstract：Objective To observe the influence of irbesartan on heart rate variability (HRV) in elderly patients with congestive heart failure (CHF). Methods CHF patients (n=32, male 19, female 13, aged from 65 to 76 and average age=71±8.9) were chosen from Oct. 2012 to Mar. 2014, and randomly divided into irbesartan group (n=17) and control group (n=15). The control group was given routine treatment including cardiotonic, diuretic, vasodilative and etiological therapies, and irbesartan group was additionally given irbesartan for 8 w. The time-domain indexes and frequency-domain indexes were detected and calculated in all patients before and after treatment. The time-domain indexes included SDNN, SDANN, SDNN-index, RMSSD and PNN50, and frequency-domain indexes included TP, LF, HF and VLF. Results After treatment, SDNN, SDANN and RMSSD increased, and TP, VLF, LF and HF increased too in irbesartan group (all P<0.05). After treatment, SDNN [(77.3±29.4) ms vs. (71.5±31.2) ms], SDANN [(78.1±25.3) ms vs. (65.8±29.6) ms] and RMSSD [(28.1±11.4) ms vs. (23.7±6.9) ms] increased, and TP [(968.6±382.4) ms2 vs. (765.4±335.2) ms2], VLF [(652.3±361.7) ms2 vs. (501.2±265.4) ms2], LF [(251.3 ±77.1) ms2 vs. (191.2±69.0) ms2] and HF [(95.4±61.3) ms2 vs. (79.5±61.1) ms2] increased in irbesartan group compared with control group (all P<0.05). Conclusion Irbesartan can improve HRV and relieve the imbalance of autonomic nervous system in elderly patients with CHF.
Keywords：Heart failureIrbesartanHeart rate variabilityNon-invasive electrocardiogram
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 498-500 )