Treatment of coronary no-reflow and slow flow with intracoronary injection of verapamil through restructured balloon catheter
XU Hao-jun
YU Zong-liang
GU Ming
ZHU Jian-zhong
GU Hui-min
Abstract：Objective To observe the curative effects of intracoronary injection of verapamil on coronary no-reflow and slow flow through restructured balloon catheter. Methods The patients with acute coronary syndrome (ACS, n=49, male 37 and female 12) and coronary no-reflow or slow flow during undergone PCI were chosen from Jan. 2009 to Jan. 2015, and then divided into control group (n=24, given intracoronary injection of verapamil through single guiding catheter) and test group (n=25, given intracoronary injection of verapamil through restructured balloon catheter). The changes of TIMI flow grading and corrected TIMI frame count (CTFC) were compared between 2 groups, and incidence of major adverse cardiovascular events (MACE) were observed in patients during hospital stay. Results TIMI flow grading and CTFC were improved all in 2 groups after treatment (all P<0.05). After treatment, TIMI flow grading increased and CTFC decreased in test group compared with control group [(2.23±0.91) vs. (2.74±0.36)], [(19.30±17.90) vs. (13.70±7.10), all P<0.05]. There were 8 cases (33.3%) with heart failure, 7 (29.2%) with malignant arrhythmia, and 1 with cardiac death in control group, and 2 (8.0%) with heart failure and 1 (4.0%) with malignant arrhythmia in test group. The incidence of MACE increased in control group compared with test group (66.7%vs. 12%, all P<0.05). Conclusion Intracoronary injection of verapamil through restructured balloon catheter can improve coronary blood flow and reduce the incidence of MACE compared with intracoronary injection of verapamil through single guiding catheter.
Keywords：Acute coronary syndromeVerapamilNo-reflowSlow flowCoronary artery interventional therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 495-497 )