Effects of joint detection of heart-type fatty acid binding protein and brain natriuretic peptide on prognosis and risk stratification in patients with chronic heart failure
HAN Peng-fei
GUI Yi-fang
JU Chuan-yu
CHEN Zhi-hui
Abstract：Objective To investigate the prognostic factors affecting chronic heart failure (CHF) and risk stratification through joint detection of heart-type fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) and follow-up study in CHF patients. Methods CHF patients (n=184, male 109, female 75, aged from 25 to 92 and average age=67±12) were chosen from Jan. 2009 to Dec. 2012, and then divided, according to whether or not having major adverse cardiovascular events (MACE), into non-MACE group (n=141) and MACE group (n=43). The levels of H-FABP and BNP were detected at admission time, and incidence of MACE was followed up after discharge for 6 m. The cut-off values of H-FABP and BNP were determined by using receiver operating characteristic curve (ROC), and then according to these cut-off values, the patients were given risk stratification and divided into normal group (n=67), low-risk group 1 (n=30), low-risk group 2 (n=33) and high-risk group (n=54). Results Age increased, percentage of cases of NYHA grade IV increased and levels of BNP and H-FABP were higher in MACE group compared with non-MACE group (all P<0.05). When the cut-off value of H-FABP was 4.3 ng/mL, the specificity was 62.1%and sensitivity was 84.0%. When the cut-off value of BNP was 200 pg/mL, the specificity was 61.9%and sensitivity was 70.2%. H-FABP>4.3 ng/mL (RR=5.415, 95%CI:2.201~13.324) and BNP>200 pg/mL (RR=2.412, 95%CI:1.016~5.731) were risk factors of MACE. There were 4 cases (6.0%) with MACE in normal group, 3 (10.0%) in low-risk group 1, 8 (24.2%) in low-risk group 2 and 28 (51.9%) in high-risk group. The incidence of MACE increased in high-risk group compared with normal group (P<0.01). Conclusion The joint detection of H-FABP and BNP is a reliable index for determining prognosis and risk stratification in CHF patients.
Keywords：Heart-type fatty acid binding proteinBrain natriuretic peptideChronic heart failureRisk stratification
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 478-481 )