Relationship between different serum levels of adiponectin and left ventricular ejection fraction or left ventricular remodeling in elderly patients with chronic heart failure
GOU Huai-yu
CHEN Yan-qiu
QU Gui-ying
Abstract：Objective To investigate the relationship between different serum levels of adiponectin (APN) and left ventricular ejection fraction (LVEF) or left ventricular remodeling in elderly patients with chronic heart failure (CHF). Methods The elderly patients with CHF (n=133, male 65, female 66 and average age=65.71±10.60) were chosen from Apr. 2012 to Apr. 2014. All patients were divided, according to NYHA standard, into grade I group (n=36), grade II group (n=32), grade III group (n=33) and grade IV group (n=32), and at the same time, according to APN level, into APN≥14mg/L group (n=53) and APN<14mg/L group (n=80). The changes of left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDd), interventricular septal thickness (IVST) and left ventricular posterior wall thickness (LVPWT) were detected by using echocardiogram, left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated, and APN level was detected. Results The serum level of APN increased significantly, and LVEDd, IVST, LVPMT, LVM and LVMI increased in grade I group, grade II group, grade III group and grade IV group compared with control group (all P<0.05). LVM, LVMI and LVEDd were significantly higher in APN≥14mg/L group than those in APN<14mg/L group (all P<0.05). The serum level of APN was negatively correlated to LVEF significantly in grade I group, grade II group, grade III group and grade IV group (r=-0.198, r=-0.211, r=-0.363, r=-0.404, all P<0.05). The serum level of APN was positively correlated to LVM, LVMI and LVEDd significantly (r=0.421, r=0.391, r=0.398, all P<0.05). Conclusion The higher the APN level was, the lower LVEF was and the severer left ventricular remodeling was in elderly patients with CHF.
Keywords：Chronic heart failureAdiponectinLeft ventricular ejection fractionVentricular remodeling
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 475-477 )