Influence of different loading doses of atorvastatin on clinical prognosis in patients with acute coronary syndrome before percutaneous coronary intervention
LIU Yong-qing
WANG Dong-mei
QI Shu-ying
ZHANG Li
RU Lei-sheng
WANG Gang
Abstract：Objective To analyze the influence of different loading doses of atorvastatin on 1-year prognosis in patients with acute coronary syndrome (ACS) before percutaneous coronary intervention (PCI). Methods ACS patients undergone successful PCI (n=101, male 72 and female 29) were chosen from Nov. 2012 to Feb. 2013, and randomly divided into 3 groups. The control group was given maintaining dose of atorvastatin (20 mg/d), and 40 mg group and 80 mg group were given atorvastatin (80 mg/d) 1 d before PCI and 40 mg/d and 80 mg/d respectively immediately just before PCI. The biochemical indexes were detected before and 1 y after PCI. The endpoint events including recurrence of angina pectoris, cardiac death and cardiac re-admission were followed up after 1 y. Results The total incidence of endpoint events increased in control group compared with 40 mg group (40.0%vs. 16.1%) and 80 mg group (40.0%vs. 13.3%, all P<0.05). In 40 mg group and 80 mg group, 1-year accumulative risk was significantly lower than that in control group (all P<0.05). The loading dose of atorvastatin before PCI was an independent protective factor of recurrence of angina pectoris. The recurrence risk of angina pectoris within 1 y was decreased by 67.3%in 40 mg group and by 68.9%in 80 mg group compared with control group. After PCI, the level of high-sensitivity C-reactive protein decreased in 40 mg group and 80 mg group compared with control group (all P<0.05). There was no case with rhabdomyolysis. There was 1 patients with alanine aminotransferase (ALT) higher 3 times than normal high limit in 40 mg group and recovered to normal after stopping mediation. Conclusion Giving atorvastatin 2 times before PCI can significantly improve 1-y prognosis in patients with ACS.
Keywords：Percutaneous coronary interventionAcute coronary syndromeClinical prognosisAtorvastatin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 461-464 )