Relationship between CYP2C19 gene polymorphism and incidence of low clopidogrel response
WU Long-mei
TIAN Xin-li
LI Jun-xia
Abstract：Objective To study the relationship between CYP2C19 gene polymorphism and incidence of low clopidogrel response (LCR). Methods The patients (n=205) undergone successful PCI and examinations of CYP2C19 gene polymorphism and thrombelastogram (TEG) were chosen from Jan. 2014 to Jan. 2015, and divided, according to whether or not carrying CYP2C19 loss-of-the function (LOF) allele, into LOF group and no-LOF group. The clinical data (general conditions, complications and combined medication) and inhibitory rate of platelet aggregation of clopidogrel were compared between 2 groups. Results The incidence of CYP2C19 LOF allele was 60.0%in all patients. The comparison in general conditions, complications and combined medication showed the difference was not statistically significant between 2 groups (all P>0.05). The outcomes of TEG showed that incidence of LCR was 53.6%in LOF group and 45.1%in no-LOF group, and difference was not statistically significant between 2 groups (χ2=1.434, P>0.05). Conclusion The incidence of LCR is slightly higher in patients with CYP2C19 LOF allele than that in those without CYP2C19 LOF allele but there is no statistical difference.
Keywords：CYP2C19 gene polymorphismThrombelastogramLow clopidogrel responseAntiplatelet therapy
Publication Date：2015-01-01
Pages：3( 458-460 )