Influence of transplantation of human umbilical cord blood stem cells on inflammatory factors in patients with ischemic cardiomyopathy
LI Jun
DONG Xiao
WANG Jun-feng
ZHOU Ming
LEI Feng-qin
LONG Hai-yan
MING Deng-feng
DANG Shu-yi
Abstract：Objective To investigate initially the influence of transplantation of human umbilical cord blood stem cells (HUCBSC) on inflammatory factors in patients with ischemic cardiomyopathy (ICM). Methods ICM patients (n=29, male 17 and female 12) were chosen from Apr. 2010 to Dec. 2013, and divided into intracoronary transplantation group (n=7), peripheral venous transplantation group (n=8) and control group (n=14). The control group was treated with normative drugs, peripheral venous transplantation group, with normative drugs+peripheral venous transplantation of HUCBSC and intracoronary transplantation group, with normative drugs+intracoronary transplantation of HUCBSC. The changes of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and B-type natriuretic peptide (BNP) were recorded respectively in 3 groups after 0 m (the same day of treatment time), 1 m, 3 m and 6 m. Results Compared with control group, BNP decreased significantly in other 2 groups after 1 m, 3 m and 6 m (all P<0.05). The levels of IL-6, CRP and TNF-αhad a descending trend after 0 m, 1 m, 3 m and 6 m in 3 groups but the difference had no statistical significance among 3 groups (all P>0.05). Conclusion Venous transplantation of HUCBSC and intracoronary transplantation of HUCBSC have not induce inflammation reaction in treatment of ICM, which are safe and effective therapies.
Keywords：Ischemic cardiomyopathyUmbilical cord blood stem cellsCell transplantationInflammation reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 454-457 )