Influence ofβ-blockers therapy on long-term prognosis at different time points in patients treated with percutaneous coronary intervention
CHEN Hui-juan
XU Ling-qi
LI Ji-ming
Abstract：Objective To investigate the influence of β-blockers therapy on long-term prognosis at different time points in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with direct percutaneous coronary intervention (PCI). Methods STEMI patients (n=351, male 260, female 91, aged from 55 to 79 and average age=65.4±10.1) were chosen from Jan. 2008 to Oct. 2012, and then divided, according to time points ofβ-blockers therapy, into early-stage group (n=229, givenβ-blockers therapy before PCI) and late-stage group (n=122, givenβ-blockers therapy after PCI and before discharge). The data were extracted from all patients who were followed up for 1.5 y. The readmission rate and mortality were recorded, and influencing factors of death was analyzed. Results The readmission rate and mortality were significantly lower in early-stage group than those in late-stage (19.7%vs. 29.5%, 1.7%vs. 5.7%, all P<0.05). Smoking (OR=2.361, 95%CI:1.132~4.924), diabetes (OR=1.897, 95%CI: 1.243~2.895), hypertension (OR=3.348, 95%CI: 1.587~7.063), multiple coronary vessels lesion (OR=1.873, 95%CI:1.024~3.426), time from onset to reperfusion>12 h (OR=1.453, 95%CI:1.097~1.925), heart rate on admission>90 time/min (OR=1.236, 95%CI:1.078~1.417) and Killip≥gradeⅡ(OR=2.818, 95%CI:1.204~6.596) were risk factors of death. Conclusion Early taking ofβ-blockers can reduce the readmission rate and mortality in patients with STEMI treated with PCI.
Keywords：Myocardial infarctionPercutaneous coronary interventionBeta-blockers
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 451-453 )