Uric acid combining N-terminal pro brain natriuretic peptide for predicting short-term poor prognosis in ;patients with acute heart failure
LI Rong
CHEN Ai-wen
SU Xing-feng
LI Shao-xia
GAN Min
CHEN Yu-huan
Abstract：Objective To discuss the predictive value of uric acid (UA) combining N-terminal pro brain natriuretic peptide (NT-proBNP) to short-term poor prognosis in patients with acute heart failure (AHF). Methods AHF patients (n=193) were chosen from Oct. 2011 to Jan. 2014, and their levels of UA and NT-ProBNP were detected and followed up for 6 m. The major adverse cardiovascular events (MACE) and rehospitalized cases due to cardiac death and/or heart failure were recorded. Results Of 193 patients, there were 23 (11.9%) died and 20 (10.4%) rehospitalized due to AHF. Single-factor regression analysis showed that predictive factors of short-term MACE risk included high levels of UA and NT-proBNP, lower glomerular filtration rate, angiotensin converting enzyme inhibitor, angiotensin receptor blocker and elderly age. Multi-factor Cox regression analysis showed that UA level was independently correlated to increase of MACE incidence (HR=1.115;95%CI:1.006~1.235;P=0.037). Kaplan-Meier survival analysis showed that risk of MACE was the highest in patients with UA>8.0 mg/dL and NT-ProBNP>4210 pg/mL (P=0.01). Conclusion UA combining NT-ProBNP can be taken as an independent predictive factor for short-term poor prognosis in AHF patients, which is more effective than any single one of them.
Keywords：Uric acidN-terminal pro brain natriuretic peptideAcute heart failure
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 390-393 )