Curative effect and safety of atorvastatin combining fenofibrate in treatment of mixed hyperlipidemia
YIN Hai-kun
ZHANG Ao
HAN Yan
Abstract：Objective To analyze the curative effect and safety of atorvastatin combining fenofibrate in treatment of mixed hyperlipidemia. Methods The elderly patients with mixed hyperlipidemia (n=120, male 68, female 52, aged from 60 to 82 and average age=67.2±5.9) were chosen from June 2010 to June 2013, and then divided randomly into study group and control group (each n=60). The control group and study group were given atorvastatin (20 mg) and study group was additionally given fenofibrate (200 mg) for 12 w. The levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and triglyceride (TG), and adverse reactions were observed and compared in 2 groups. Results There were 27 patients with significant efficacy and 30 with efficacy, and the total effective rate was 95.0%in study group, which was higher than that in control group (83.3%, P<0.05). Compared with control group, TG, TC and LDL-C decreased and HDL-C increased (all P<0.05) in study group after treatment for 6 w, and TG, TC and LDL-C decreased and HDL-C increased in study group after treatment for 12 w (all P<0.01). The difference in incidence of adverse reactions had no statistical significance (8.3% vs. 6.7%, P>0.05) between 2 groups. Conclusion Atorvastatin combining fenofibrate has higher clinical efficacy in patients with mixed hyperlipidemia, which is worthy of clinic application.
Keywords：Mixed hyperlipidemiaAtorvastatinFenofibrateCurative effect
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 378-380 )