Significance of visfatin and adiponectin to heart failure after treatment of acute myocardial infarction ;with percutaneous coronary intervention

CHEN Wei

doi:10.3969/j.1674-4055.2015.03.25

Abstract：Objective To discuss the significance of visfatin and adiponectin to heart failure after treatment of acute myocardial infarction (AMI) with percutaneous coronary intervention (PCI). Methods The patients with AMI undergone PCI (n=123, male 76, female 47) were chosen from Jan. 2012 to June 2014, and among them there were 49 with heart failure (HF group) and 74 without heart failure (NHF group). Other 30 patients with chronic angina pectoris were chosen as AP group, and 20 healthy controls were chosen as normal group. The indexes of cardiac troponin I (cTnI), creatine kinase MB (CK-MB), N-terminal pro brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), white blood cell count (WBC), neutrophil count (NE), low-density lipoprotein-cholesterol (LDL-C), visfatin and adiponectin were detected. The changes of LVEF, LVEDd and LVEDs were detected by using ultrasonography. Results Compared with normal group, in other 3 groups visfatin level increased and adiponectin level decreased (all P<0.05). Adiponectin level decreased in HF group compared with AP group and NHF group (all P<0.05). In HF group, visfatin level was positively correlated to cTnI, CK-MB, NT-proBNP, TG, TC, LDL-C, CRP, WBC, NE and LVEDs (r=0.568, r=0.485, r=0.502, r=0.541, r=0.394, r=0.429, r=0.205, r=0.366, r=0.389and r=0.305, all P<0.05), and negatively correlated to LVEF (r=-0.296, P<0.05). Adiponectin level was negatively correlated to cTnI, CK-MB, TG, TC, LDL-C, CRP and NE (r=-0.354, r=-0.425, r=-0.298, r=-0.331, r=-0.354, r=-0.253, r=-0.374, all P<0.05). Conclusion Visfatin and adiponectin are correlated to heart failure after treatment of AMI with PCI, which can be taken as predictive indexes in clinic.