Perioperative effect of Danhong Injection in patients with unstable angina pectoris during percutaneous ;coronary intervention
ZHOU Wei-wei
ZHOU Ying
ZHANG Hua-wei
Abstract：Objective To review the perioperative effect of Danhong Injection in patients with unstable angina pectoris (UAP) during percutaneous coronary intervention (PCI). Methods UAP patients (n=100, male 70, female 30, aged from 42 to 77 and average age=58.0±9.2) were chosen from Apr. 2012 to Apr. 2014, and then divide randomly into control group and treatment group (each n=50). All groups were given routine drugs and PCI, and treatment group was given additionally Danhong Injection 1 to 3 d before PCI and totally for 7 d during perioperative period. The clinical efficacy was observed in all patients. The vein blood samples were collected 24 h before PCI and 24 h after PCI for detecting the changes of high-sensitivity C-reactive protein (hs-CRP) interleukin-6 (IL-6) and cardiac troponin T (cTnT). Results There were 27 cases (54%) with significant efficacy and 14 (28%) with efficacy, and the total effective rate was 82%in treatment group, and 21 cases (42%) with significant efficacy and 11 (22%) with efficacy, and the total effective rate was 64%in control group (P<0.05). In control group, IL-6 decreased and cTnT increased after PCI, and hs-CRP and IL-6 decreased (all P<0.05). After PCI, hs-CRP [(0.40 ±0.70) mg/dl vs. (0.20±0.21) mg/dl], IL-6 [(2.52±2.49) pg/ml vs. (2.37±1.68) pg/ml] and cTnT [(0.12±0.0) ng/ml vs. (0.09±0.05) ng/ml] all decreased in treatment group compared with control group (all P<0.05). Conclusion Danhong Injection can improve the clinical efficacy, inhibit perioperative inflammatory reactions and protect ischemic myocardium in patients with UAP.
Keywords：Danhong InjectionUnstable angina pectorisDuring percutaneous coronary interventionMyocardial protection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 336-338 )