Influences of Compound Danshen Gutta Pills on circadian rhythm of blood pressure, high-sensitivity C-reactive ;protein and heart function in patients with non-dipper hypertension
HE Zhi-wei
LIU Hui-qin
LI Jian-xiang
Abstract：Objective To investigate the influences of Compound Danshen Gutta Pills (taking for a long time) on circadian rhythm of blood pressure (BP), high-sensitivity C-reactive protein (hs-CRP) and heart function in patients with non-dipper hypertension. Methods The patients (n=178, male 92, female 86 and aged from 45 to 76) were chosen from Jan. 2009 to Jan. 2013. All patients were divided into treatment group (n=88) and control group (n=90) according to random digits table, and treated with levoamlodipine maleate (2.5 mg) once a day. Those whose BP was still higher than 140/90 mmHg (1 mmHg=0.133kPa)were given valsartan. The treatment group was additionally given Compound Danshen Gutta Pills (10 pills for 3 times a day) for 6 m. The changes of BP were monitored dynamically, circadian rhythm of BP was observed, effective rate of changes of BP circadian rhythm was calculated, hs-CRP was detected and heart function was monitored by using echocardiogram. Results All BP indexes were improved in 2 groups after treatment (all P<0.01). After treatment, nighttime systolic blood pressure (SBP), nighttime diastolic blood pressure (DBP), nighttime BP loading and daytime BP loading all decreased in treatment group compared with control group (all P<0.05). The effective rate of changes of SBP or DBP circadian rhythm were significantly improved in treatment group compared with control group after treatment (41.01%vs. 78.38%, 42.11%vs. 75.00%, all P<0.05). The level of hs-CRP decreased and E/A increased in treatment group after treatment (all P<0.05). The level of hs-CRP decreased in treatment group compared with control group after treatment [(1.85±0.93) mg/L vs. (0.86±0.71) mg/L, P<0.01]. There were no adverse reactions as rash and stomachach observed in 2 groups. Conclusion Compound Danshen Gutta Pills (taking for a long time) can ameliorate circadian rhythm of BP, reduce hs-CRP level and improve cardiac diastolic function in patients with non-dipper hypertension.
Keywords：Compound Danshen Gutta PillsNon-dipper hypertensionCircadian rhythm of blood pressureHigh-sensitivity C-reactive proteinHeart function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 331-333 )