Curative effect of salvianolate on acute myocardial infarction
LI Lin
WU Long-fei
LIU Fu-rong
LIU Chun-yan
DENG Jing-yu
ZHU Yu
KANG Guo-ping
LIU Yi-ling
Abstract：Objective To study the curative effect of salvianolate on acute myocardial infarction (AMI). Methods The AMI patients (n=131, male 75, female 56 and aged from 45 to 75) were chosen from Jan. 2012 to Jan. 2014, and then randomly divided into treatment group (n=65) and control group (n=66). The treatment was given to 2 groups according to AMI treatment guideline, and treatment group was additionally given intravenous drip of salvianolate (200 mg/d) for 7 d. The indexes of LVEF, brain natriuretic peptide (BNP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), white blood cells count (WBC) and C-reactive protein (CRP) were detected at different time points including hospitalized time (d0), and after hospitalized for 3 d (d3), 7 d (d7) and 14 d (d14). The mortality within 30 d after hospitalization and incidence of ventricular arrhythmias during hospitalization were compared between 2 groups. Results At d3 and d7, BNP was significantly lower and LVEF was higher in treatment group than those in control group (all P<0.05). At d7 and d14, LDL-C and TC were significantly lower in treatment group than those in control group (all P<0.05). CRP was lower at d3, d7 and d14, and WBC was higher at d3 and d7 and lower at d14 in treatment group than those in control group (all P<0.05). During hospitalization there were 4 cases in treatment group and 5 in control group with ventricular tachycardia (6.2%vs. 7.6%), and 8 in treatment group and 6 in control group with frequent premature ventricular contraction (12.3%vs. 9.1%, all P>0.05). There were 8 cases died in treatment group and 8 cases died in control group (12.3%vs. 12.1%) within 30 d after hospitalization (P=0.974). The hospitalizing days were 10 d in treatment group and 13 d in control group (P=0.0078 by Log-rank test). Conclusion Salvianolate can improve heart function, shorten hospitalization time, relieve inflammatory reactions and reduce levels of TC and LDL-C.
Keywords：SalvianolateAcute myocardial infarctionLeft ventricular ejection fractionBrain natriuretic peptide
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 317-319 )