Influence of circumferential pulmonary vein isolation on electrophysiologic properties of pulmonary veins in patients with paroxysmal atrial fibrillation
ZHENG Zhi-tao
YANG Yan-zong
XIA Yun-long
GAO Lian-jun
ZHANG Shu-long
YANG Dong-hui
YIN Xiao-meng
CHANG Dong
Abstract：Objective To investigate influence of circumferential pulmonary vein isolation (CPVI) on electrophysiologic properties of pulmonary vein.Methods The patients (n=26) with paroxysmal atrial fibrillation (PAF), without curative effect after treated with anti-arrhythmia drugs and for the first time with CPVI, were chosen. The effective refractory period (ERP) and relative refractory period (RRP) of pulmonary vein and left atrium were detected, and the changes of ERP and RRP of pulmonary vein and left atrium were compared before and after CPVI. Results There were totally 104 pulmonary veins isolated in 26 patients and they had sinus rhythm immediately after surgery. Before and after CPVI, diastolic pacing threshold of pulmonary vein was, respectively, (3.2±0.6) V vs. (3.3±0.5) V, (P>0.05). Before CPVI, ERP (n=82) and RRP (n=35) of pulmonary vein were shorter than those of left atrium (187±60) msvs. (229±31) ms (P<0.001) and (223±45) msvs. (261±34) ms (P<0.05). After CPVI, ERP (n=47) and RRP (n=26) of pulmonary vein had no statistical difference compared with those of left atrium (245±38) msvs. (234±43) ms (P>0.05) and (268±44) msvs. (245±41) ms (P>0.05). After CPVI, ERP (n=47) and RRP (n=21) of pulmonary vein were significantly longer than those before CPVI (245±38) msvs. (187±76) ms (P<0.05) and (259±44) msvs. (230±47) ms (P<0.05).Conclusion CPVI insulates the electric conduction between pulmonary vein and left atrium, meanwhile changes and decreases electrophysiologic and arrhythmogenic properties of pulmonary vein.
Keywords：Paroxysmal atrial fibrillationPulmonary veinCircumferential pulmonary vein isolation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 258-261 )