Safety of metoprolol in patients with atrial fibrillation complicating long R-R interval
CHEN Dong-fang
XIE Ming-ming
TIAN Jun
XI Lian-ying
JI Yun-yun
WU Li-rong
Abstract：Objective To investigate the safety of metoprolol in treatment of atrial fibrillation (AF) complicating long R-R interval.Methods The patients (n=68) were divided into sleep-related group (n=44) and sleep-unrelated group (n=24) according to the relationship between long R-R interval and sleep before treatment. All patients were monitored with 24 h Holter before and after treatment. The changes of long R-R interval and symptoms related to bradycardia were compared in and between 2 groups before and after metoprolol treatment. Results After metoprolol treatment for 1 m, the longest R-R interval during sleep increased than before in 2 groups [sleep-related group: (2650±146.0) msvs. (2315±129.5) ms; sleep-unrelated group: (2549±201.9) msvs. (2764±171.1) ms;P<0.05)]. Under non-sleep state, the longest R-R interval significantly increased [(2262±105.8) msvs. (2406±120.2) ms;P<0.05], and 24 h array number of long R-R interval increased [(48.6±13.5) timesvs. (63.8±10.9) times;P<0.05] in sleep-unrelated group. The longest R-R interval and 24-h array number of long R-R interval had no significant changes in sleep-related group (P>0.05). There was no patient with amaurosis or syncope in sleep-related group, and 2 patients (8.33%) with amaurosis but no one with syncope in sleep-unrelated group.Conclusion It is relatively safe to administrate metoprolol for controlling ventricular rate in AF patients with sleep-related long R-R interval, while in patients with sleep-unrelated long R-R interval, it must be careful to administrate metoprolol and the symptoms related to bradycardia should be observed.
Keywords：HolterAtrial fibrillationLong R-R intervalMetoprololSafety
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 237-239 )