Correlation between serum homocysteine or lipoprotein (a) and coronary heart disease
ZHAO Wei-lin
YANG Fan
YUAN Li-pei
ZHAO Luo-sha
Abstract：Objective To discuss the correlation between serum homocysteine (Hcy) or lipoprotein (a) [LP (a)] and coronary heart disease (CHD).Methods CHD patients (n=84) diagnosed with coronary angiography (CAG) were divided into stable angina pectoris group (SAP group,n=28) and acute coronary syndrome group (ACS group, n=56), and other 56 patients with selective CHD and normal CAG were chosen as control group. The levels of serum Hcy and LP (a) were detected in all groups, and all patients were given Gensini scoring according to their CAG outcomes. The multiple risk factors of CHD were given multivariate Logistic regression analysis.Results The difference in levels of serum Hcy and LP (a) had statistical significance among 3 groups (P<0.05). Pearson linear correlation analysis showed that there was no correlation between Hcy level and LP (a) level (r=0.240,P>0.05), and Gensini integral was positively correlated to Hcy level and LP (a) level respectively (r=0.78,r=0.75; allP<0.05). The multivariate Logistic regression analysis showed that Hcy (OR=1.287, 95%CI: 1.027~1.791) and LP (a) (OR=3.038, 95%CI: 2.984~3.431) were independent risk factors of CHD.Conclusion Higher levels of Hcy and LP (a) are independent risk factors of CHD and correlated to the severity of CHD.
Keywords：Coronary heart diseaseSerum homocysteineLipoprotein (a)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 229-231 )