Influences of recombinant human brain natriuretic peptide on heart function and left ventricular remodeling in high risk patients with early acute myocardial infarction
QIAO Hui-bin
LI Li
GUO Ren-wei
LI Jian-guo
WANG Quan-yi
Abstract：Objective To study the influences of recombinant human brain natriuretic peptide (rhBNP) on heart function and left ventricular remodeling in high risk patients with early acute myocardial infarction (AMI). Methods The patients [n=52, male 28, female 24, aged from 41 to 75 and average age=(60.8±9.8)] with first time AMI were chosen from Jan. 2013 to Sept. 2014. All patients were randomly divided into rhBNP group (n=23) and control group (n=29), and control group was given only routine therapy and rhBNP group was given rhBNP for 3-5 d besides of routine therapy. The changes of NT-proBNP, LVEF and LVEDd were detected immediately and 1 w after hospitalization, and Killip scores and cardiac death were recorded after 1 w.Results The difference in Killip scores and percentage of cardiac death had no statistical significance between 2 groups 1 w after hospitalization (all P>0.05). The level of NT-proBNP increased in control group and decreased in rhBNP group after treatment (all P<0.01), and LVEF and LVEDd all increased in 2 groups after treatment (allP<0.05). After treatment, NT-proBNP level decreased [(2204.94±830.90) pg/mlvs. (1498.29±707.33) pg/ml] and LVEDd decreased [(53.60±5.25) mm vs. (49.87±3.36) mm] in rhBNP group compared with control group (P<0.01).Conclusion The administration of rhBNP as early as possible can effectively improve heart function and inhibit early left ventricular remodeling in high risk patients with early AMI.
Keywords：Recombinant human brain natriuretic peptideAcute myocardial infarctionHeart functionLeft ventricular remodeling
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 218-220 )