Correlation between inflammatory cytokines and heart rate variability in patients with unstable angina pectoris
MA Du-fang
YAO Xiao-dong
ZHUANG Xin
WU Bo
WANG Yan
LI Xiao
Abstract：Objective To study the relationship between inflammatory cytokines and heart rate variability (HRV) in patients with unstable angina pectoris (UAP).Methods UAP patients (n=40, female 26, male 14 and aged from 50 to 80) were chosen from June 2013 to June 2014, and then divided into [high sensitivity C-reactive protein (hs-CRP)<1.0 mg/L group,n=15], [hs-CRP=(1.0~3.0) mg/L group,n=16], and (hs-CRP>3.0mg/L group,n=9). All patients were given 24h Holter for detecting HRV and calculating time-domain index and frequency-domain index. The levels of hs-CRP and interleukin-6 (IL-6) were detected. The relationships between the natural logarithms of hs-CRP or IL-6 and SDNN or RMSSD were analyzed.Results SDNN and RMSSD decreased inhs- CRP>3.0mg/L group compared with hs-CRP=(1.0~3.0) mg/L group (allP<0.05). The comparison in frequency-domain index showed that LF, HF, VLF and TP decreased gradually as hs-CRP increased but there was no statistical difference among all groups (allP>0.05). The single factor correlation analysis showed that the natural logarithms of hs-CRP was negatively correlated to SDNN (r=-0.365,P=0.022), while not correlated to RMSSD, and the natural logarithms of IL-6 was negatively correlated to SDNN (r=-0.700,P<0.001) and RMSSD (r=-0.457,P=0.003).Conclusion The decrease of HRV is correlated to the increases of inflammatory cytokines (hs-CRP and IL-6) in UAP patients.
Keywords：Unstable angina pectorisHeart rate variabilityHigh sensitivity C-reactive proteinInterleukin-6Correlation analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 211-214,224 )