Changes of expressions of cholesterol efflux genes in peripheral blood leukocytes in hypertensive patients
TONG Qi-guang
WU Chang-yan
YUE Zhi-gang
XU Hui
LIU Ya
MAO Wen
ZHANG Miao-miao
WU Di
LIU Peng
HU Da-yi
Abstract：Objective To study the expressions of cholesterol efflux genes in peripheral blood leukocytes in hypertensive patients.Methods The patients [hypertension group,n=13, male 7, female 6 and average age=(66.54 ±11.72)] and health cases [control group,n=11, male 8, female 3 and average age=(62.36±9.27)] were chosen from Mar. 2013 to May 2013. The mRNA expressions of apolipoprotein A1 (ApoA1), ATP binding cassette transporter A1 (ABCA1) and ATP binding cassette transporter G1 (ABCG1) in peripheral blood leukocytes were detected by using real-time fluorescence quantitative polymerase chain reaction (RT-PCR) in 2 groups.Results Compared with control group, ABCA1 mRNA expression decreased [(2.38±0.82)vs. (0.47±0.20)] and ApoAI mRNA expression also decreased [(2.19±0.86)vs. (0.11±0.06)] in hypertension group (allP<0.05). The expression of ABCG1 mRNA had no statistical difference between 2 groups (P>0.05).Conclusion The decreased expressions of cholesterol efflux genes in peripheral blood leukocytes may be one of mechanisms of hypertension resulting in atherosclerosis in hypertensive patients.
Keywords：HypertensionApolipoprotein A1ATP binding cassette transporter A1ATP binding cassette transporter G1
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 196-198 )